Program

3rd Conference on translational medicine on pathogenesis and therapy of
immune-mediated diseases

CHAIRMAN: DOMENICO MAVILIO

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SEPTEMBER 29th, 2014

12:00 pm Meeting Registration
SATELLITE SYMPOSIA ON NEXT GENERATION SEQUENCING AND TRANSCRIPTOME
Supported by Illumina and Charles River

Chairmen: Marco CassatellaAnna Villa

2:00 pm Dave Delano, Senior Product Manager Illumina, San Diego, CA, USA
Illumina solutions for trascriptomics
2:20 pm Tania Sorg, IGBMC, Inserm, Strasbourg, France
Mouse phenogenomics to evaluate transcriptome-driven hypothesis
2:40 pm Enzo Medico, Candiolo Cancer Institute and University of Torino, Italy
Analysis of tumor-stroma interactions by species-specific transcriptional profiling of patient-derived xenografts
3:00 pm Raffaele Calogero, University of Torino, Italy
Circulating non-coding RNA as Biomarker in Human Diseases
3:20 pm DISCUSSION PANEL

4:15 pm OPENING CEREMONY AND WELCOME
Domenico Mavilio
Humanitas Research Hospital and University of Milan, Italy, Chairman of the Meeting

4:30 pm Opening Humanitas Lecture
Chairman: Alberto Mantovani
Humanitas Research Hospital and University of Milan, Milan Italy

Speaker: JULES HOFFMANN Innate Immunity : from Flies to Humans
5:30 pm Welcome reception with Italian aperitifs

 

SEPTEMBER 30th, 2014


MORNING SESSION

1st Session – IMMUNITY, AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES

Chairmen: Marco Gattorno ,  Pietro Invernizzi
Liver Autoimmunity
8:30 am Palak Trivedi, University of Birmingham, UK
Primary Sclerosing Cholangitis: an autoimmune disease driven by the gut
8:50 am Ansgar W. Lohse, University Medical Center, Hamburg, Germany
Pathogenesis of autoimmune hepatitis: too little or too much T reg activity?
9:10 am David Jones, Newcastle University, U.K.
Autoimmune liver diseases – Primary Biliary Cirrhosis
9:30 am DISCUSSION PANEL
9:50 am Matteo Iannacone, Istituto San Raffaele, Milan, Italy
In vivo imaging of antiviral immune responses in the liver
10:10 am SHORT TALK SELECTED FROM SUBMITTED ABSTRACTS
Kelly L. Hudspeth, Humanitas Research Hospital, Milan, Italy
Homeostasis of hepatic NK cells

10:20 am COFFEE BREAK & POSTER VIEW

Special “Bench to the Bed Side” combined talks

Chairman: Gianluigi Condorelli, Humanitas Research Hospital, Milan, Italy
Exome sequencing reveals new inflammation-associated genes: ADA2 deficiency is linked to vasculopathy
10:50 am Manfred Boehm, NHLBI/NIH, Bethesda, MD, USA – Bench Side
11:10 am Ivona Aksentijevich, NHGRI/NIH, Bethesda, MD, USA – Bed Side

11:30 am Discussion Panel

Autoinflammatory Diseases
11:40 am Anna Rubartelli, IRCCS, San Martino Hospital, Genova, Italy
The critical role of stress in IL-1β and regulatory cytokine production by healthy and NLRP3-mutated monocytes
12:00 am Richard Siegel, NIAIMS, NIH, Bethesda, MD, USA
Metabolic and Cell Biological Consequences of TNFR1 mutations in TRAPS
12:20 pm Dirk Foell, University Hospital Muenster. Germany
Phagocyte-derived danger signals as driving forces in autoinflammatory diseases
12:40 pm DISCUSSION PANEL

1:00 pm SHORT TALKS SELECTED FROM SUBMITTED ABSTRACTS
Markus Hoffmann,University of Erlangen-Nuremberg, Germany
The oxidative burst mediates anti-inflammatory clearance of dead cells in a mouse model of Systemic lupus Erythematosus and inflammatory arthritis
Monika Jurkowska, Institute of Rheumatology, Warsaw, Poland
HLA-DRB1 alleles frequency in Polish patients with Mixed Connective Tissue Disease: search for risk and protective alleles
Edgar Fernadez-Malavè, Immunology, Faculty of Medicine, Complutense University, Madrid, Spain
N-ras is a negative regulator of the pro-inflammatory potential of dendritic cells

1:45 pm LUNCHEON SEMINAR Supported by Space
Chairman: Michele Bombardieri, Queen Mary University of London, U.K.
Speaker: Claudio Doglioni, Istituto San Raffaele, Milan, Italy
Role of  the pathologist in project of Translational Immunology

2:30 pm COFFEE & POSTER VIEW

AFTERNOON SESSION

2nd Session – INNATE IMMUNITY AND VIRUSES

Chairmen: Luis Montaner Enrico Lugli

3:00 pm Michael Malim, Kings College, London, U.K
HIV-1 Infection, Type-1 Interferon and Viral Restriction
3:20 pm Daniel Douek, VRC, NIAID/NIH, Bethesda, MD, USA
Perturbing Type I Interferon Signaling in Acute SIV Infection
3:40 pm Genoveffa Franchini, NCI – NIH, Bethesda, MD, USA
Molecular and Immunological Correlates of Vaccine Induced Protection  from SIVmac251 acquisition
4:00 pm DISCUSSION PANEL4:20 pm Julie Dechanet-Merville, CNRS, Bordeaux, France
Cell stress recognition by CMV-induced gamma-delta T cells Cell stress recognition by CMV-induced gamma-delta T cells
4:40 pm Christian Munz, University of Zurich, Switzerland
NK cell responses during primary EBV infection
5:00 pm DISCUSSION PANEL

5:10 pm COFFEE BREAK

5:40 pm Luigi Naldini, Istituto San Raffaele and Telethon Insitute, Milan, Italy
Lentiviruses: from basic research to gene therapy of immunologic disorders
6:10 pm SHORT TALKS SELECTED FROM SUBMITTED ABSTRACTS
Monica Cappelletti, Cincinnati Children’s Hospital Research Foundation, Ohio, USA
The type IFN axis regulates infection- and inflammation-induced pretermbirth
Stephen Noel Waggoner, Cincinnati Children’s Hospital Medical Center, Ohio, USA
Natural killer cell cross-talk with myeloid cells in pathogenesis of chronic virus infection
Monica Vaccari, NCI, NIH, Bethesda, MD, USA
The decrease in the number of T Follicular Regulatory cells drives the expansion of T Follicular Helper cells in SIV infected macaques
Melodie L. Weller, NIDCR, NIH, Bethesda, MD, USA
Hepatitis delta virus detected in salivary glands of Sjögren’s syndrome patients and induces disease phenotype in vivo

7:00 pm POSTER DISCUSSION Open Bar available during the poster discussion

Chairmen:
Session of Immunity, Autoimmune and Autoinflammatory Diseases
Marco Gattorno, Istituto Giannina Gaslini, Genova, Italy – Pietro Invernizzi, Humanitas Research Hospital, Milan Italy
Session of Innate Immunity and Viruses
Luis Montaner, Wistar Institute, Philadelphia, PA, USA – Enrico Lugli, Humanitas Research Hospital, Milan, Italy
Session of Innate Immunity and Tumor
Massimo Locati, Humanitas Research Hospital and University of Milan, Italy – Carmelo Carlo Stella, Humanitas Research Hospital and University of Milan, Italy
Session of Innate Immunity and IBD
Stefania Vetrano, Humanitas Research Hospital, Milan, Italy – Antonino Spinelli, Humanitas Research Hospital and University of Milan, Italy
8:30 pm Social Dinner with Live Music for all participants – Award Ceremony for the winner of fellowships

OCTOBER 1st, 2014


MORNING SESSION
3rd session – INNATE IMMUNITY AND TUMOR
Chairmen: Massimo Locati, Carmelo Carlo Stella

8:30 am Adrian Hayday, King’s College, London, UK
A new (and optimistic) perspective on the suppression of Tumour-Infiltrating Lymphocytes
8:50 am Jo Van Ginderachter, VIB, Gent, Belgium
Macrophage and dendritic cell heterogeneity in the tumor microenvironment
9:10 am Vincenzo Bronte, University of Verona, Italy
Myeloid suppressor cells and inflammation-driven tumors
9:30 am Haribabu Bodduluri, University of Lousville, KY, USA
Chemoattractant Regulated Leukocyte Networks in Tumors
9:50 am DISCUSSION PANEL

10:10 am COFFEE BREAK

10:40 am Ralf Küppers, University of Duisburg-Essen, Germany
The role of the microenvironment in lymphoma pathogenesis
11:00 am Constantine Mitsiades, Dana-Farber Cancer Institute, Boston, USA
Topic: host immune response in multiple myeloma
11:20 am DISCUSSION PANEL

11:50 Supported by Perkin Elmer
R.C. Lloyd, PerkinElmer, Hopkinton, MA
Phenotyping TILs in situ: Automated Enumeration of FOXP3+ Regulatory T Cells in Follicular Lymphoma

12:05 pm SHORT TALK SELECTED FROM SUBMITTED ABSTRACTS
Marco Macagno, University of Turin, Italy
Role of Perforin+ Cells in the Microenvironment of ErbB2+ Salivary and Mammary Carcinomas in Transgenic Male Mice
Chiara Porta, University of Piemonte Orientale, Novara, Italy
The p50 NF-κB subunit shapes pro-tumor inflammation supporting colorectal cancer development
Eleonora Timperi, University La Sapienza, Rome, Italy
Regulatory T cells expressing Helios, OX40 and CD39 in human colorectal cancers
Valentino Le Noci, University of Milan, Italy
Combined aerosolization of TLR9 and TLR3 agonists in the treatment of lung Metastases

12:45 pm POSTER VIEW
1:15 pm LUNCHEON SEMINAR Supported by Dompé
Chairman: Pier Adelchi Ruffini
Speaker: Piero Dalerba, Columbia University, NY, USA
Cancer Stem Cells: molecular identity and clinical significance

2:00 pm COFFEE & POSTER VIEW

 

AFTERNOON SESSION
4th session – INNATE IMMUNITY AND INFLAMMATORY BOWEL DISEASES

Chairmen: Silvio Danese, Antonino Spinelli

2:30 pm Marco Colonna, Washington University, St. Louis, MO, USA
Topic: Innate lymphoid cells and gut homeostasis
2:50 pm Stefania Vetrano, Humanitas Research Hospital, Milan, Italy
The epithelium in IBD: a break in the wall?
3:10 pm Matthieu Allez, University of Paris, France
Manipulation of the innate or the adaptive immune system as a novel approach for IBD?
3:30 pm Christoph Becker, Friedrich-Alexander-University, University Medical Center, Erlangen, Germany
Is Crohn’s disease an immune defect or an immune excess?
3:50 pm Britta Siegmund, Charité – Universitätsmedizin Berlin
Cross-Talk of non-immune cells and immune cells in the regulation of IBD
4:10 pm Nicola Gagliani, Yale University, New Haven, CT, USA
The complex role of Th17 and Tr1 cells in the regulation of intestinal homeostasis
4:30 pm DISCUSSION PANEL

4:50 pm SHORT TALK SELECTED FROM SUBMITTED ABSTRACTS
Silvia D’Alessio, Humanitas Research Hospital, Milan, Italy
Conditional deletion of Prep1 in the intestinal epithelium alters epithelial homeostasis, intestinal development, and controls colitis susceptibility
Lisa L. Korn, Perelman School of Medicine, University of Pennsylvania, PA, USA
Regulatory T cells occupy an isolated niche in the intestine that is antigen-independent
Rajat Madan, University of Virginia, Charlottesville, VA, USA
Leptin signaling alters susceptibility to Clostridium difficile by controlling host Inflammation
Rosita Rigoni, University of Milan, Italy
Microbial signals control inflammation and autoimmunity induced by hypomorphic RAG defects

 

Closing Lecture- Humanitas Lecture 

Chairmen: Agostino Riva – Guido Poli

Speaker: ROBERT GALLO       HIV-1 Infection from the early years to the current needs and problems

 

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